Journal
MOLECULAR BIOTECHNOLOGY
Volume 26, Issue 2, Pages 147-163Publisher
HUMANA PRESS INC
DOI: 10.1385/MB:26:2:147
Keywords
MALDI-TOF; SNP analysis; genotyping; quantitative MALDI-TOF; gene-expression analysis; resequencing; SNP discovery; DNA pooling
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Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has developed during the past decade into a versatile tool for biopolymer analysis. The aim of this review is to summarize this development and outline the applications, which have been enabled for routine use in the field of nucleic acid analysis. These include the analysis of mutations, the resequencing of amplicons with a known reference sequence, and the quantitative analysis of gene expression and allelic frequencies in complex DNA mixtures.
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