Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 12, Issue 3, Pages 571-576Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2003.11.001
Keywords
isonicotinylhydrazide; sulphonamides; Mannich bases; antibacterial activity; toxicity; statistical analysis
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Biologically active Mannich bases with heteroaromatic ring system have been synthesised employing Mannich reaction of isonicotinyl hydrazide with various sulphonamides/secondary amines. They were analysed by elemental analysis and characterized by uv, ir, H-1 nmr spectroscopic studies. The Mannich bases were screened for their antibacterial activity against various gram positive and gram negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic. (C) 2003 Elsevier Ltd. All rights reserved.
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