Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 189, Issue 3, Pages 459-461Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/381123
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Contemporary influenza vaccines are standardized with respect to their content of hemagglutinin, the major virus antigen. Although the immunizing effect of viral neuraminidase - the less abundant of the 2 major surface glycoproteins - has been well documented in experimental animals, the importance of the purified recombinant protein has not yet been adequately assessed in animals or humans. We demonstrate that different lots of a baculovirus-derived recombinant N2 protein, in the absence of other influenza virus proteins, can induce neuraminidase-specific antibodies, reduce the replication of both homologous and heterovariant virus in mice, and suppress disease, as it is manifested by total body weight loss.
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