Journal
CELL AND TISSUE RESEARCH
Volume 315, Issue 2, Pages 279-283Publisher
SPRINGER
DOI: 10.1007/s00441-003-0821-2
Keywords
antigen; cancer; immunotherapy; sperm; testis; human
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Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4. SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23. It is expressed in a limited number of normal tissues, notably the pancreas and testis, but is switched on and greatly upregulated in a wide range of neoplastic tissues. The data therefore strongly suggests that SPAG4 expression is a potential clinically relevant cancer marker.
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