Journal
JOURNAL OF PSYCHOSOMATIC RESEARCH
Volume 56, Issue 2, Pages 207-212Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0022-3999(03)00598-1
Keywords
chronic fatigue syndrome; polysomnography; sleep; twins
Categories
Funding
- NIAID NIH HHS [U19 AI 38429] Funding Source: Medline
Ask authors/readers for more resources
Purpose: Chronic fatigue syndrome (CFS) is characterized by profound fatigue accompanied by disturbances of sleep, cognition, mood, and other symptoms. Our objective was to describe sleep architecture in CFS-discordant twin pairs. Methods: We conducted a co-twin control study of 22 pairs of monozygotic twins where one twin met criteria for CFS and the co-twin was healthy. Twins underwent two nights of polysomnography. Results: The percentage of Stage 3 and REM sleep was greater among the CFS twins than their healthy co-twins (Pless than or equal to.05 for both), but no other differences in sleep architecture including sleep latency, REM latency, and total sleep time were observed. Compared to their co-twins, CFS twins had higher values for the apnea-hypopnea index and apnea-hypopnea arousal index (Pless than or equal to.05 for both). Conclusion: These results do not provide strong evidence for a major role for abnormalities in sleep architecture in CFS. Respiration appears impaired in CFS, but these clinical abnormalities cannot alone account for the prominence of sleep complaints in this illness. The co-twin control methodology highlights the importance of selecting well-matched control subjects. (C) 2004 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available