Journal
BEHAVIORAL NEUROSCIENCE
Volume 118, Issue 1, Pages 223-236Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.1.223
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- NIMH NIH HHS [MH61492, MH60013] Funding Source: Medline
- NINDS NIH HHS [R01 NS41636-02] Funding Source: Medline
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Experimental data and computational models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning and increases proactive interference (E. DeRosa & M. E. Hasselmo, 2000; M. E. Hasselmo & J. M. Bower, 1993). The results presented here provide evidence in humans supporting these hypotheses. Young healthy subjects first learned baseline word pairs (A-B) and, after a delay, learned additional overlapping (A-C) and nonoverlapping (D-E) word pairs. As predicted, when compared with subjects who received the active placebo glycopyrrolate (4 mug/kg) and subjects who were not injected, those who received scopolamine (8 mug/kg) showed (a) overall impairment in new word paired-associate learning, but no impairment in cued recall of previously learned associates; and (b) greater impairment in learning overlapping (A-C) compared with nonoverlapping (D-E) paired associates.
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