Journal
IUBMB LIFE
Volume 56, Issue 2, Pages 89-93Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15216540410001668055
Keywords
calcium channel; sodium channel; norepinephrine transporter; nicotinic acetylcholine receptor; NMDA receptor; neurotensin receptor
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Cone snails have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in normal and diseased states. A number of these peptides have shown efficacy in vivo, including inhibitors of calcium channels, the norepinephrine transporter, nicotinic acetylcholine receptors, NMDA receptors and neurotensin receptors, with several having undergone pre-clinical or clinical development for the treatment of pain.
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