Journal
TRANSGENIC RESEARCH
Volume 13, Issue 1, Pages 81-85Publisher
SPRINGER
DOI: 10.1023/B:TRAG.0000017177.35197.89
Keywords
antisense RNA; laminin receptor; LRP/LR; neuron-specific enolase (NSE); prion; PrP
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The 37-kDa/67-kDa laminin receptor (LRP/LR) plays a major role in the propagation of PrPSc, the abnormal form of the prion protein. In order to ablate the expression of LRP/LR in mouse brain we generated transgenic mice ectopically expressing antisense LRP RNA in the brain under control of the neuron-specific enolase (NSE) promoter. Hemizygous transgenic mice TgN(NSEasLRP)2 showed a significant reduction of LRP/LR protein levels in hippocampal and cerebellar brain regions. These mice might act as powerful tools to investigate the role of the laminin receptor in scrapie pathogenesis.
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