Journal
BIOCHEMISTRY AND CELL BIOLOGY
Volume 82, Issue 1, Pages 1-17Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/o03-080
Keywords
phospholipase A(2); arachidonic acid; eicosanoid; phospholipid
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Funding
- NHLBI NIH HHS [HL34303, HL61378] Funding Source: Medline
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Mammalian cells have developed specific pathways for the incorporation, remodeling, and release of arachidonic acid. Acyltransferase and transacylase pathways function to regulate the levels of esterified arachidonic acid in specific phospholipid pools. There are several distinct, differentially regulated phospholipases A(2) in cells that mediate agonist-induced release of arachidonic acid. These pathways are important in controlling cellular levels of free arachidonic acid. Both arachidonic acid and its oxygenated metabolites are potent bioactive mediators that regulate a myriad of physiological and pathophysiological processes.
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