Journal
GENES & DEVELOPMENT
Volume 18, Issue 3, Pages 306-319Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1162404
Keywords
daf2; GH; growth retardation; aging; testis; Akt; Sir2
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Funding
- NCRR NIH HHS [R24 RR011102, RR11102] Funding Source: Medline
- NIA NIH HHS [AG20915, R01 AG020915] Funding Source: Medline
- NICHD NIH HHS [R01 HD034807] Funding Source: Medline
- NIDDK NIH HHS [DK07766, T32 DK007766] Funding Source: Medline
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Overexpression of the short isoform of p53 (p44) has unexpectedly uncovered a role for p53 in the regulation of size and life span in the mouse. Hyperactivation of the insulin-like growth factor (IGF) signaling axis by p44 sets in motion a kinase cascade that clamps potentially unimpeded growth through p21Cip1. This suggests that pathways of gene activity known to regulate longevity in lower organisms are linked in mammals via p53 to mechanisms for controlling cell proliferation. Thus, appropriate expression of the short and long p53 isoforms might maintain a balance between tumor suppression and tissue regeneration, a major requisite for long mammalian life span.
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