Journal
ELECTROPHORESIS
Volume 25, Issue 3, Pages 428-436Publisher
WILEY
DOI: 10.1002/elps.200305707
Keywords
capillary electrophoresis; large-volume sample stacking using the EOF pump; nonsteroidal anti-inflammatory drugs; water samples
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Several on-column sample preconcentration modes-large-volume sample stacking using the EOF pump (LVSEP), LVSEP with anion-selective exhaustive injection (LVSEP-ASEI) and field-amplified sample injection with sample matrix removal using the electroosmotic flow (EOF) pump (FAEP)-were used to analyze some nonsteroidal anti-inflammatory drugs (NSAIDs) by capillary electrophoresis, and then compared. Methanol was the background electrolyte solvent to suppress the EOF The effect of the type and length of the solvent plug, and the sample injection time were investigated in FAEP to determine the conditions that provided the best response. LVSEP, LVSEP-ASEI, and FAEP improved the sensitivity of the peak area by 100-, 1200-, and 1800-fold, respectively. The methodology developed, in combination with solid-phase extraction (SPE), was applied to the analysis of water samples.
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