Journal
BIOTECHNOLOGY LETTERS
Volume 26, Issue 3, Pages 235-238Publisher
SPRINGER
DOI: 10.1023/B:BILE.0000013721.78288.1d
Keywords
fed-batch culture; nisin; nutritional limitation
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Nisin production was improved under nutritional limitation in fed-batch culture of Lactococcus lactis. Nisin titre reached 3887 IU ml(-1) by a slow feeding of sucrose and 4131 IU ml(-1) by slow feeding of nitrogen source, which were, respectively, 64% and 74% above the values in batch culture.
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