Journal
BEHAVIORAL NEUROSCIENCE
Volume 118, Issue 1, Pages 97-110Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.1.97
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- NIMH NIH HHS [R29MH57865] Funding Source: Medline
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The authors compared the effects of pharmacological inactivation of the dorsal hippocampus (DH) or ventral hippocampus (VH) on Pavlovian fear conditioning in rats. Freezing behavior served as the measure of fear. Pretraining infusions of muscimol, a GABA(A) receptor agonist, into the VH disrupted auditory, but not contextual, fear conditioning; DH infusions did not affect fear conditioning. Pretesting inactivation of the VH or DH did not affect the expression of conditional freezing. Pretraining electrolytic lesions of the VH reproduced the effects of muscimol infusions, whereas posttraining VH lesions disrupted both auditory and contextual freezing. Hence, neurons in the VH are importantly involved in the acquisition of auditory fear conditioning and the expression of auditory and contextual fear under some conditions.
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