Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 27, Issue 2, Pages 248-250Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.27.248
Keywords
antidiabetic activity; exercise; KK-Ay; Momordica charantia; Cucurbitaceae
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The antidiabetic activity of Momordica charantia L. (Cucurbitaceae) with exercise was investigated in KK-Ay mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of Momordica charantia L. (MC) with exercise reduced the blood glucose of KK-Ay mice 5 weeks after oral administration (p<0.001), and also significantly lowered the plasma insulin of KK-Ay mice under similar conditions (p<0.01). The blood glucose of MC with exercise is lower than that of MC only,or exercise only 5 weeks after the administration. MC with exercise decreased blood glucose in a glucose tolerance test. These results suggest that MC with exercise is useful for type 2 diabetic cure.
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