Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 161, Issue 2, Pages 359-361Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.161.2.359
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that the Val and Met alleles Would be associated with deficits in imitation learning and reversal learning, respectively. Method: Twenty-six patients with schizophrenia and schizoaffective disorder completed a task requiring alternation between imitation and reversal rules. Objective: The catechol O-methyltransferase (COMT) Val(158)Met polymorphism has been associated with cognitive and behavioral phenotypes in schizophrenia. Whether COMT genotype is beneficial may depend on phenotype definition. The authors examined the effects of COMT genotype on a task that distinguishes imitation from reversal learning. They hypothesized Results: Met homozygotes showed better acquisition of the imitation rule but greater deficit shifting from imitation to reversal. Val homozygotes had poorer imitation performance and slower reaction times. Conclusions: The Met allele, by increasing tonic dopamine, may promote cognitive stability but limit cognitive flexibility.
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