Journal
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Volume 21, Issue 2, Pages 55-57Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JARG.0000025939.26834.93
Keywords
FISH; IVF; ICSI; preimplantation development
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Purpose: To study if second day intracytoplasmic sperm injection (ICSI) results in chromosomal abnormalities in the embryos. Methods: Rescue ICSI was performed on 14 metaphase II (MII) oocytes after unsuccessful conventional IVF, four were fertilized. Fluorescent in situ hybridization ( FISH) was performed on these four embryos and was informative for three. Results: There were two tetraploid embryos, one mosaic embryo with trisomy 21, tetrasomy 18, and tetrasomy for sex chromosomes in one cell and trisomy 22 in another cell. Conclusions: We discourage the use of second day ICSI due to the observed increase in chromosomal abnormalities in these embryos.
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