Journal
BIOCHEMISTRY AND CELL BIOLOGY
Volume 82, Issue 1, Pages 254-262Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/o03-089
Keywords
phosphatidylinositol transfer protein; secretion; lipid signaling; phosphomositide
Categories
Ask authors/readers for more resources
Phosphatidylinositol/phosphatidylcholine transfer proteins (PITPs) are ubiquitous and highly conserved proteins that are believed to regulate lipid-mediated signaling events. Their ubiquity and conservation notwithstanding, PITPs remain remarkably uninvestigated. Little is known about the coupling of specific PITPs to explicit cellular functions or the mechanisms by which PITPs interface with apppropriate cellular functions. The available information indicates a role for these proteins in regulating the interface between lipid metabolism and membrane trafficking in yeast, signaling in plant development, the trafficking of specialized luminal cargo in mammalian enterocytes, and neurological function in mammals. Herein, we review recent advances in PITP biology and discuss as yet unresolved issues in this field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available