Journal
TOPICS IN CATALYSIS
Volume 27, Issue 1-4, Pages 3-9Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:TOCA.0000013536.27551.13
Keywords
galacto-hexodialdose; galactose oxidase; one-pot; cascade catalysis; multistep
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Various cascade routes starting from D-galactose derivatives-via 6-CH2OH oxidation catalyzed by galactose oxidase-are reported as one-pot procedures. The approach consists of combined bio- and chemocatalytic reactions as well as spontaneous'' chemical conversions. Workup is avoided by using compatible aqueous reaction conditions for all the consecutive reactions involved. A great benefit of this method is that D-galactose containing di-, tri- and oligosaccharides can be modified without the use of protecting groups and without any isolation and/or purification of intermediate products in these syntheses. The one-pot cascades, consisting of up to five consecutive transformations, gave rapid access to more than 40 uronic acid, amino sugar and deoxy sugar derivatives through enzymatic, homogeneous and heterogeneous catalytic conversions in water under mild conditions.
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