Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 15, Issue 1, Pages 49-60Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2003.10.005
Keywords
interleukin-6 (IL-6); osteoprotegerin (OPG); receptor activator of nuclear factor-kappa B ligand (RANKL)
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All osteogenic cells (osteoclasts, osteoblasts) contribute individually to bone remodeling. Their cellular interactions control their cellular activities and the bone remodeling intensity. These interactions can be established either through a cell-cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or their soluble receptor chains. These factors can act directly on osteogenic cells and their precursors to control differentiation, formation and functions (matrix formation, mineralization, resorption...). Here, we present the involvement of three groups of cytokines which seem to be of particular importance in bone physiology: interleukin-6 (IL-6), tumor necrosis factor -alpha(TNF-alpha) (TNF-)/IL-1, and the more recently known triad osteoprotegerin (OPG)/receptor activator of NF-kappaB (RANK)/RANK ligand (RANKL). The interactions between these three groups are presented within the framework of bone resorption pathophysiology such as tumor associated osteolysis. The central role of the OPG/RANK/RANKL triad is pointed out. (C) 2003 Elsevier Ltd. All rights reserved.
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