Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 68, Issue 2, Pages 428-432Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.68.428
Keywords
isoflavone; HMG-CoA reductase; genistein; cholesterol; soybean
Ask authors/readers for more resources
Isoflavones identified as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in soybean paste were assayed using the catalytic portion of Syrian hamster HMG-CoA reductase, and the kinetic values were measured using HMG-CoA and NADPH. The inhibition of HMG-CoA reductase by these inhibitors was competitive with HMG-CoA and noncompetitive with NADPH. K-i values for genistein, daidzein, and glycitein were 27.7, 49.5, and 94.7 mum, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available