Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 113, Issue 3, Pages 321-333Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200420925
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Funding
- NCI NIH HHS [R01 CA097946, R01CA97946] Funding Source: Medline
- NIDDK NIH HHS [R21DK063603, R01DK53707, R21 DK063603] Funding Source: Medline
- NIGMS NIH HHS [R01GM63270, R01 GM063270] Funding Source: Medline
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Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the ecology of the indigenous microbiota. A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia.
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