Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 346, Issue 2-3, Pages 171-184Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200303191
Keywords
biomimetic catalyst; drug metabolism; isoniazid; metalloporphyrin; oxidation
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An overview of the biomimetic catalysts used in the oxidative activation of drugs is given, with an emphasis on the use of synthetic metalloporphyrins as models of cytochrome P450 to mimic the in vivo metabolism of pharmaceuticals. In addition, a special focus is directed towards the recent results from the authors' group on the oxidative activation of isoniazid, an antitubercular drug.
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