Journal
EUROPEAN JOURNAL OF BIOCHEMISTRY
Volume 271, Issue 4, Pages 780-784Publisher
WILEY
DOI: 10.1111/j.1432-1033.2004.03981.x
Keywords
lichenized ascomycete; Collema cristatum; mycosporine; photo protective activity; UV-B
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A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.
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