Journal
INFECTION AND IMMUNITY
Volume 72, Issue 2, Pages 1150-1154Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.2.1150-1154.2004
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By creating mutations in the Burkholderia mallei ATCC 23344 animal pathogen-like type III secretion system (TTSS), this study analyzes the correlation between type III secretion and the pathogenicity of ATCC 23344 in vivo. Mutagenesis demonstrated that a functional TTSS was required for the full pathogenicity of ATCC 23344 in the BALB/c mouse and Syrian hamster models of infection. However, vaccination with each mutant failed to elicit a protective immunity against challenge with wild-type ATCC 23344.
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