Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 16, Issue 2, Pages 193-206Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S1050-4648(03)00078-0
Keywords
live vaccine; cross protection; immune response; Aeromonas hydrophila; Aeromonas salmonicida; Oncorhynchus mykiss; rainbow trout
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An auxotrophic aroA mutant of the Aeromonas hydrophila AG2 strain is a live attenuated vaccine against A. hydrophila infection in rainbow trout (Oncorhynchus mykiss). The protection conferred by the live attenuated vaccine against A. salmonicida strains is reported here, and several parameters of the specific and non-specific immune response in vaccinated trout were characterised. Vaccination with a dose of 10(7) cells/fish of the aroA mutant elicited significant protection against the Hooke and DK30 strains of A. salmonicida (relative percent survival RPS >60%). This cross-protection correlated moderately with the activation of the humoral and cellular specific immune responses, which show cross-reactivity against antigens shared by the two bacterial species, and a moderate increase in the lysozyme and antiprotease activities in the serum of vaccinated trout. (C) 2003 Elsevier Ltd. All rights reserved.
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