Journal
NATURE CELL BIOLOGY
Volume 6, Issue 2, Pages 154-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1094
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Funding
- NCI NIH HHS [CA40042] Funding Source: Medline
- NICHD NIH HHS [HD07528-01] Funding Source: Medline
- NIGMS NIH HHS [GM23244, GM47607, R01 GM047607] Funding Source: Medline
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Cell migration is a complex, highly regulated process that involves the continuous formation and disassembly of adhesions ( adhesion turnover). Adhesion formation takes place at the leading edge of protrusions, whereas disassembly occurs both at the cell rear and at the base of protrusions. Despite the importance of these processes in migration, the mechanisms that regulate adhesion formation and disassembly remain largely unknown. Here we develop quantitative assays to measure the rate of incorporation of molecules into adhesions and the departure of these proteins from adhesions. Using these assays, we show that kinases and adaptor molecules, including focal adhesion kinase (FAK), Src, p130CAS, paxillin, extracellular signal-regulated kinase (ERK) and myosin light-chain kinase (MLCK) are critical for adhesion turnover at the cell front, a process central to migration.
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