Journal
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Volume 30, Issue 1, Pages 19-29Publisher
WILEY
DOI: 10.1046/j.0305-1846.2003.00496.x
Keywords
Alzheimer disease; cell cycle; hippocampus; p53; p73
Categories
Funding
- NINDS NIH HHS [NS42902, NS38648, R01 NS038648, R01 NS042902] Funding Source: Medline
Ask authors/readers for more resources
The molecular mechanisms that regulate neuronal survival vs. death during Alzheimer disease (AD) remain unclear. Nonetheless, a number of recent studies indicate that increased expression or altered subcellular distribution of numerous cell cycle proteins during AD may contribute to disease pathogenesis. Because homologues of p53, a key regulatory protein in the cell cycle, such as p73, have been identified and shown to participate in cellular differentiation and death pathways, we examined the expression and distribution of p73 in the hippocampus of eight control and 16 AD subjects. In control subjects, hippocampal pyramidal neurones exhibit p73 immunoreactivity that is distributed predominately in the cytoplasm. In AD hippocampus, increased levels of p73 are located in the nucleus of pyramidal neurones and p73 is located in dystrophic neurites and cytoskeletal pathology. Immunoblot analysis confirmed the presence of p73 in the hippocampus. These data indicate that p73 is expressed within hippocampal pyramidal neurones and exhibits altered subcellular distribution in AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available