Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 27, Issue 2, Pages 251-255Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.27.251
Keywords
Phyllanthus emblica; Euphorbiaceae; antiproliferative activity; MK-1 cell; HeLa cell; B16F10 cell
Categories
Ask authors/readers for more resources
Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available