Journal
EUKARYOTIC CELL
Volume 3, Issue 1, Pages 241-244Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.3.1.241-244.2004
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Funding
- NIAID NIH HHS [T32 AI007323, R03 AI054496, 2-T32-AI-07323, AI054496, R01 AI034536, AI34536] Funding Source: Medline
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The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans-splicing competence. In Trypanosoma brucei, RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3'-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U-28 pseudouridylation was unaffected.
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