Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 61, Issue 4, Pages 417-436Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-003-3242-1
Keywords
oxygen control; Rhodobacter sphaeroides; FnrL; redox regulation; Prr two-component signal transduction; regulatory system; PpsR; AppA; blue light repression
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Funding
- NIGMS NIH HHS [GM15590] Funding Source: Medline
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The means by which oxygen intervenes in gene expression has been examined in considerable detail in the metabolically versatile bacterium Rhodobacter sphaeroides. Three regulatory systems are now known in this organism, which are used singly and in combination to modulate genes in response to changing oxygen availability. The outcome of these regulatory events is that the molecular machinery is present for the cell to obtain energy by means that are best suited to prevailing conditions, while at the same time maintaining cellular redox balance. Here, we explore the dangers associated with molecular oxygen relative to the various metabolisms used by R. sphaeroides, and then present the most recent findings regarding the features and operation of each of the three regulatory systems which collectively mediate oxygen control in this organism.
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