Journal
SYNLETT
Volume -, Issue 2, Pages 235-238Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2003-43374
Keywords
biginelli condensation; cupric chloride; cupric sulphate; dihydropyrimidinones; three-component reactions
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Cupric chloride dihydrate catalyzes the three-component Biginelli condensation between an aldehyde, a beta-ketoester and urea or thiourea under microwave irradiation in the absence of solvent to yield various substituted 3,4-dihydropyrimidin-2(1H)-ones. The reaction is also effective when performed at room temperature in acetonitrile or at 100 degreesC in a solvent free approach, without any side reactions as observed by Biginelli and others.
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