Journal
CURRENT BIOLOGY
Volume 14, Issue 3, Pages R129-R138Publisher
CELL PRESS
DOI: 10.1016/j.cub.2004.01.023
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Cell-cell signaling mediated by the receptor Notch is used widely across the metazoans to determine cell fate and regulate pattern formation. Notch signals via a conserved regulated intramembrane proteolysis. Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time.
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