Journal
JOURNAL OF NEUROBIOLOGY
Volume 58, Issue 2, Pages 189-200Publisher
WILEY
DOI: 10.1002/neu.10314
Keywords
microtubule; dynein; neurofilament; retrograde transport; motor protein; dynactin; AAA ATPase
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Funding
- NICHD NIH HHS [HD40182] Funding Source: Medline
- NIGMS NIH HHS [GM47434] Funding Source: Medline
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Cytoplasmic dynein has long been thought to be responsible for retrograde axonal transport. As the number of cellular roles for this multifunctional protein has expanded, the complexity of its contribution to axonal transport has increased. In this article the increasing evidence for a role for cytoplasmic dynein in anterograde as well as retrograde transport is discussed. The current status of the complex dynein cargo-binding mechanism is evaluated. Finally, recent genetic evidence supporting a role in axonal transport and revealing a role in neurodegenerative conditions is reviewed. (C) 2003 Wiley Periodicals, Inc.
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