Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 336, Issue 1, Pages 61-67Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2003.12.002
Keywords
quasispecies; VSV; experimental evolution; genetic bottleneck; Muller's ratchet
Categories
Funding
- NIAID NIH HHS [R01-AI45686] Funding Source: Medline
Ask authors/readers for more resources
Muller's ratchet is a principle of evolutionary genetics describing mutant accumulation in populations that are repeatedly subjected to genetic bottleneck. The immediate effect of Muller's ratchet, overall loss of fitness, has been confirmed in several viral systems belonging to different groups. This report shows that in addition to fitness loss, genetic bottlenecks also have longer-term effects, namely changes in the capacity of viral populations to adapt. Thus, vesicular stomatitis virus strains with a history of genetic bottleneck have lower adaptability than strains maintained at relatively large population sizes. This lower adaptability is illustrated by their reduced ability to regain fitness and by their inability to outcompete wildtype populations in situations where the initial fitness of the bottlenecked mutant is the same or even higher than the initial fitness of the wild-type. (C) 2003 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available