Journal
CHEMBIOCHEM
Volume 5, Issue 2, Pages 183-189Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200300762
Keywords
combinatorial library; consensus design; consensus sequence; protein design; protein engineering
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Consensus design is a valuable protein-engineering method that is based on statistical information derived from sequence alignments of homologous proteins. Recently, consensus design was adapted to repeat proteins. We discuss the potential of this novel repeat-based approach for the design of consensus repeat proteins and repeat protein libraries and summarize recent results from such experiments.
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