Journal
NEUROREPORT
Volume 15, Issue 2, Pages 231-234Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200402090-00003
Keywords
hippocampus; nitric oxide synthase (NOS); N-Nitro-L-arginine-methyl ester (NAME); phosphorylated cAMP response element binding; (pCREB) protein; polysialylated neural cell adhesion molecule (PSA-NCAM)
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It is well known that nitric oxide (NO) acts downstream of NMDA receptor activation, which regulates the neural plasticity in the brain. In the present study, the effect of L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor, on neural plasticity in the hippocampus was investigated. L-NAME increased the expression of PSA-NCAM and pCREB in the adult rat hippocampus. The colocalization of PSA-NCAM and pCREB indicates a possible relationship between the two in the granule cell layer in the dentate gyrus. Our results demonstrate that NO, as a subsignal of NMDA receptors, could be involved in the structural plasticity of the granule cell layer in the dentate gyrus by regulating the expression of PSA-NCAM and pCREB in the hippocampus.
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