Journal
TETRAHEDRON-ASYMMETRY
Volume 15, Issue 3, Pages 519-523Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2003.12.013
Keywords
-
Ask authors/readers for more resources
The feasibility of enantiomeric excess (ee) prediction is demonstrated for asymmetric oxazaborolidine mediated ketone reduction. A quantitative structure-selectivity (QSSR) model of chiral oxazaborolidines was created by using multivariate data analysis. High-throughput methods and regression techniques were used to correlate the model with the ee's of reactions with a training set and to predict the ee's for an additional set of oxazaborolidines. The predicted ee's corresponded well with the actual values, indicating that the model is very useful for the initial selection of catalysts for screening experiments. (C) 2003 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available