Journal
JOURNAL OF CONTROLLED RELEASE
Volume 94, Issue 2-3, Pages 447-451Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2003.10.024
Keywords
pH-sensitive liposomes; poly(N-isopropylacrylamide); poly(ethylene glycol)
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pH-sensitive liposomes were prepared using a terminally-alkylated copolymer of N-isopropylacrylamide (NIPAM) and methacrylic acid (MAA) and poly(ethylene glycol) (PEG) phospholipid derivative. The pH-triggered content release was evaluated before and after incubation in serum. Pharmacokinetic and biodistribution profiles of the formulations were established in rats. This study showed that a pH-sensitive, serum-stable and long-circulating liposomal formulation can be produced.
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