Journal
CANCER LETTERS
Volume 204, Issue 1, Pages 23-31Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2003.09.021
Keywords
isothiocyanate; isothiocyanate transport; multidrug resistance associated protein-1; P-glycoprotein-1; allyl isothiocyanate; benzyl isothiocyanate; phenethyl isothiocyanate
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Funding
- NCI NIH HHS [CA80962, CA23074, R01 CA080962] Funding Source: Medline
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Many dietary isothiocyanates (ITCs) are potent anticarcinogenic agents. ITCs rapidly accumulate to high concentrations in cells as a result of conjugation with intracellular thiols, especially glutathione (GSH). The anticarcinogenic activity of ITCs depends on, at least partly, their accumulation in cells. We report that three major anticarcinogenic ITCs, including allyl-ITC, benzyl-ITC, and phenethyl-ITC, were rapidly exported, upon accumulation in cells, mainly in the forms of GSH- and cysteinylglycine-conjugates, apparently involving MRP-1 and Pgp-1. These findings are consistent with our previous results regarding cellular export of another anticarcinogenic ITC, sulforaphane, and suggest a common cellular response to ITCs. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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