Journal
SCIENCE
Volume 303, Issue 5660, Pages 1014-1016Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1090839
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- NIGMS NIH HHS [GM49985] Funding Source: Medline
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The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.
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