Journal
LANCET
Volume 363, Issue 9408, Pages 535-536Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(04)15542-6
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Funding
- NCI NIH HHS [CA77658, CA23318, CA21115, CA16058, CA101140, CA31946] Funding Source: Medline
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The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic. relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors-TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2-in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.
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