Journal
JOURNAL OF IMMUNOLOGY
Volume 172, Issue 4, Pages 2155-2162Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.172.4.2155
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Funding
- NIA NIH HHS [AG-17618, R01 AG017618-03, R01 AG017618-04S1, R01 AG017618-04, R01 AG017618-02, AG-15474] Funding Source: Medline
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The capacity to class switch the IgH chain is critical to the effectiveness of humoral immune responses. We show that in vitro-stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes (IgG1, G2a, G3, and E), class switch recombination (CSR), and induction of the E2A-encoded transcription factor E47. E47 has previously been shown to be. required for CSR, at least in part via expression of the activation-induced cytidine deaminase. Our studies show that impaired induction of E47, and subsequently activation-induced cytidine deaminase, contribute to poor CSR and production of secondary isotypes in senescence.
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