Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 217, Issue 2, Pages 211-216Publisher
ELSEVIER
DOI: 10.1016/j.jns.2003.10.012
Keywords
multiple sclerosis; early phase; depressive symptoms; cognition; processing speed; working memory
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Depressive symptoms may influence neuropsychological functioning negatively. A substantial proportion of multiple sclerosis (MS) patients exhibit neuropsychological impairments and depressive symptomatology is more common in MS as compared to healthy controls and to other neurological diseases. The objectives of the present study were to assess information processing speed, working memory and executive functions in early phase MS and to investigate whether severity of depressive symptoms account for these aspects of cognition in MS. The patients show slowed information processing speed and impaired working memory, whereas executive functioning, as measured with the Wisconsin Card Sorting Test, is unaffected. Depressive symptoms account for slowed information processing speed, but not for impaired working memory. (C) 2003 Elsevier B.V. All rights reserved.
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