Journal
BIOPHYSICAL CHEMISTRY
Volume 107, Issue 3, Pages 243-253Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bpc.2003.09.013
Keywords
nucleation-dependent polymerization model; sigmoid; kinetic constants
Ask authors/readers for more resources
Requirements for generating remarkable sigmoidal time-course of aggregation are found in the nucleation-dependent polymerization model by a numerical calculation method; i.e. there are optimum values of the kinetic constants to afford prominent sigmoidal character by inducing slightly unfavorable nucleation. However, if the nucleus formation is too unfavorable, sigmoidal character is again decreased. This result is in contrast to the generally accepted idea that sigmoid is induced by thermodynamically unfavorable nucleation phase. (C) 2003 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available