Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 125B, Issue 1, Pages 83-86Publisher
WILEY
DOI: 10.1002/ajmg.b.20091
Keywords
allele sharing methods; linkage analysis; population isolates
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Funding
- NIMH NIH HHS [MH-49499, MH-01748, MH-00916] Funding Source: Medline
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We report further evidence for our previous suggestion [Garner et al., 2001: Am J Hum Genet 68:1061-1064] of a locus on 5q predisposing to bipolar I disorder (BP-I) in an extended Costa Rican pedigree. We geno-typed additional microsatellite markers in this region and applied a multi-point non-parametric linkage analysis (SimWalk2). Significant identity-by-descent allele sharing among affected relatives was observed for all of the 20 markers tested in a segment of approximately 15 cM. Most affected individuals shared a single haplotype over this region; breaks within this haplotype may suggest a more restricted candidate location for a BP-I gene. These results support the suggestion that a locus at 5q31-33, together with a previously reported locus at 18q22-23, may provide the major genetic risk for BP-I in this family. (C) 2003 Wiley-Liss, Inc.
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