Journal
JOURNAL OF IMMUNOLOGY
Volume 172, Issue 4, Pages 2021-2029Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.172.4.2021
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Funding
- NIAID NIH HHS [R01 AI039167, R01 AI050747, R01AI39167, R21AI53748, R01AI54707, R21 AI053748] Funding Source: Medline
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The MHC class I-related receptor, FcRn, plays a central role in regulating the serum levels of IgG. FeRn is expressed in endothelial cells, suggesting that these cells may be involved in maintaining IgG levels. We have used live cell imaging of FcRn-green fluorescent protein transfected human endothelial cells to analyze the intracellular events that control IgG homeostasis. We show that segregation of FcRn-IgG complexes from unbound IgG occurs in the sorting endosome. FcRn or FcRn-IgG complexes are gradually depleted from sorting endosomes to ultimately generate multivesicular bodies whose contents are destined for lysosomal degradation. In addition, the pathways taken by FcRn and the transferrin receptor overlap, despite distinct mechanisms of ligand uptake. The studies provide a dynamic view of the trafficking of FcRn and its ligand and have relevance to understanding how FcRn functions to maintain IgG homeostasis.
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