Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 422, Issue 2, Pages 119-124Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2003.12.029
Keywords
tyrosine phosphatase; peroxiredoxin; peroxidase; OxyR; reactive oxygen species; oxidative stress; thiolate; sulfenic acid; hydrogen peroxide; redox
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Funding
- NHLBI NIH HHS [R01 HL074324] Funding Source: Medline
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Despite much recent interest in the biochemistry of reactive oxygen species, the mechanisms by which hydrogen peroxide (H2O2) functions in mammalian cells remain poorly defined. Proposed mechanisms for sensing H2O2 in mammalian cells include inactivation of protein tyrosine phosphatases and dual specificity phosphatases as well as inactivation of peroxiredoxins. In this critical review, proteins proposed to serve as sensors for H2O2 in mammals will be compared to peroxidases, catalases, and the bacterial H2O2 sensor OxyR for their ability to react with H2O2, in the context of our current knowledge concerning the concentrations of H2O2 present in cells. (C) 2004 Elsevier Inc. All rights reserved.
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