Journal
JOURNAL OF CELL BIOLOGY
Volume 164, Issue 4, Pages 527-534Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200311119
Keywords
CREB; PKA; gene expression; compartmentalization; signal transduction
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Funding
- NIAMS NIH HHS [R01 AR032147, AR32147] Funding Source: Medline
- NICHD NIH HHS [HD38722, HD42060, R01 HD038722] Funding Source: Medline
- NIGMS NIH HHS [GM62328, T32 GM007739, R01 GM062328, GM07739] Funding Source: Medline
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Bicarbonate-responsive soluble adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
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