4.4 Article

First synthesis of antimalarial Machaeriols A and B

Journal

TETRAHEDRON LETTERS
Volume 45, Issue 8, Pages 1689-1691

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2003.12.107

Keywords

Machaeriols; hetero-Diels-Alder reaction; Suzuki coupling

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A short and efficient synthesis of the naturally occurring antimalarial compounds, Machaeriols A and B, from commercially available citronellal via hetero-Diels-Alder cycloaddition and Suzuki coupling in 33% overall yield is described. (C) 2003 Elsevier Ltd. All rights reserved.

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