Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 34, Issue 3, Pages 517-523Publisher
ELSEVIER
DOI: 10.1016/S0731-7085(03)00576-4
Keywords
carvedilol; beta-cyclodextrin; inclusion complex; NMR; microwave irradiation; molecular modeling
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An inclusion complex of beta-cyclodextrin with carvedilol was prepared by using a convenient new method of microwave irradiation. Phase-solubility studies demonstrated the ability of beta-cyclodextrins to complex with carvedilol and increase drug solubility. The structure of inclusion complex was determined by fluorescence spectroscopy and H-1 NMR, C-13 NMR measurements in solution. The solid inclusion was characterised by infrared spectroscopy, differential scanning calorimetry (DSC) and element analysis. These experimental results confirmed the existence of 1:2 inclusion complex of carvedilol with beta-cyclodextrin, the formation constant of complex was determined by the fluorescence method. Molecular modeling predicted the energy-minimized structure of the complex. (C) 2003 Elsevier B.V. All tights reserved.
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